New Apple Ingredient Discovery Guard strong muscles
Natural component of apple peels Found to Help Prevent Muscle Weakening
In search of an effective method for preventing muscle loss that comes with aging and disease, researchers have located a natural compound that is very promising.
The results presented in the June issue of Cell Metabolism (Cell Press publication) identify a natural component of apple peels known as ursolic acid as a promising therapy for newnutritional widespread and debilitating condition that affects almost everyone one time or another.
"Muscle wasting is a frequent companion of illness and aging," said the researchers from the University of Iowa, Iowa City. "It prolongs hospitalization, delays recoveries and in some cases prevents people go at home. It is not well understood and there is no medicine for it. "
The research team first examined what happens to gene activity in muscles under conditions that promote decay. These studies are is up to 63 genes that change in response to fasting in both people and mice and 29 others who move their expression in the muscles of the two people who are fasting and those with spinal cord injury. Comparison of these gene expression signatures for signature cells treated with over 1,300 bioactive small molecules led them to ursolic acid as a compound with effects that could counteract those of atrophy.
"Ursolic acid is an interesting natural compound," they said. "It's part of a normal diet as an apple peels component. They always say that an apple a day keeps the doctor away ..."
The researchers then gave ursolic acid to fasted laboratory subjects. These experiments showed that ursolic acid could protect against muscle weakness as expected. When ursolic acid was added to the food of normal subjects during one week period, the muscles have increased. These effects were traced back to a better insulin signaling in muscle and to corrections in the signatures of genes related to atrophy.
Subjects given Ursolic acid has also become thinner and had lower blood levels of glucose, cholesterol and triglycerides. The results suggest that ursolic acid may be responsible for some of the overall benefits of a healthy diet.
"We know that if you eat a balanced diet like mom told us to eat you get this material," the researchers explain, "People who eat junk food do not get this."
It is not yet clear whether the results will translate to human patients, but the goal now is to "determine whether it can help people." If so, they do not yet know whether ursolic acid at levels that could be consumed as part of a normal diet of strength, or perhaps not enough
Natural component of apple peels Found to Help Prevent Muscle Weakening
In search of an effective method for preventing muscle loss that comes with aging and disease, researchers have located a natural compound that is very promising.
The results presented in the June issue of Cell Metabolism (Cell Press publication) identify a natural component of apple peels known as ursolic acid as a promising therapy for newnutritional widespread and debilitating condition that affects almost everyone one time or another.
"Muscle wasting is a frequent companion of illness and aging," said the researchers from the University of Iowa, Iowa City. "It prolongs hospitalization, delays recoveries and in some cases prevents people go at home. It is not well understood and there is no medicine for it. "
The research team first examined what happens to gene activity in muscles under conditions that promote decay. These studies are is up to 63 genes that change in response to fasting in both people and mice and 29 others who move their expression in the muscles of the two people who are fasting and those with spinal cord injury. Comparison of these gene expression signatures for signature cells treated with over 1,300 bioactive small molecules led them to ursolic acid as a compound with effects that could counteract those of atrophy.
"Ursolic acid is an interesting natural compound," they said. "It's part of a normal diet as an apple peels component. They always say that an apple a day keeps the doctor away ..."
The researchers then gave ursolic acid to fasted laboratory subjects. These experiments showed that ursolic acid could protect against muscle weakness as expected. When ursolic acid was added to the food of normal subjects during one week period, the muscles have increased. These effects were traced back to a better insulin signaling in muscle and to corrections in the signatures of genes related to atrophy.
Subjects given Ursolic acid has also become thinner and had lower blood levels of glucose, cholesterol and triglycerides. The results suggest that ursolic acid may be responsible for some of the overall benefits of a healthy diet.
"We know that if you eat a balanced diet like mom told us to eat you get this material," the researchers explain, "People who eat junk food do not get this."
It is not yet clear whether the results will translate to human patients, but the goal now is to "determine whether it can help people." If so, they do not yet know whether ursolic acid at levels that could be consumed as part of a normal diet of strength, or perhaps not enough
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